Toxicological significance of methylation and sulfurization in the metabolic process of inorganic arsenics: Active species caused by metabolic redox and molecular aspects of redox homeostasis in cell transformation

报告题目：Toxicological significance of methylation and sulfurization in the metabolic process of inorganic arsenics: Active species caused by metabolic redox and molecular aspects of redox homeostasis in cell transformation

主讲人：山中健三 教授 日本大学药学部副部长

时间：2018年10月19日（星期五）下午15:30-16:30

地点：威尼斯欢乐娱人城精品医学部威尼斯欢乐娱人城精品杏林会议室（1412会议室）

CURRICULUM VITAE

Kenzo Yamanaka

October 2018

GENERAL

Kenzo Yamanaka, Ph.D., Pharmacist, Prof. & Vice Dean at Nihon University School of Pharmacy, Chief Laboratory of Environmental Toxicology and Carcinogenesis, School of pharmacy, Nihon University

7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan

Tel & Fax: (+81)47-465-6077

E-mail: yamanaka.kenzo@nihon-u.ac.jp

EDCATION

1991  PhD  Radio Biochemistry       University of Shizuoka Graduate School of Pharmaceutical Scienceswith Prof.Shoji Okada

1983  MS   Environmental Biochemistry   Shizuoka College of Pharmacy, Graduate School with Prof. Shoji Okada

1981 BS, Pharmacisit  Hygienic Chemistry  Nihon University, School of Pharmacy with Prof. Ryoji Sawamura

WORK HISTRY & POSITION

1983 Senior Fellow, Research Institute of Biological Science, Lion Corp., Japan

1985 Research Associate, Laboratory of Hygienic Chemistry, Nihon University School of Pharmacy with Prof. Ryoji Sawamura

1993 Assistant Professor, Laboratory of Clinical Biochemistry, Nihon University School of Pharmacy with Prof., Dean, Akira Hasegawa

1998-2003 Visiting Fellow, The institute of Physical and Chemical Research (RIKEN)

2000 Associate Professor, Laboratory of Environmental Toxicology and Carcinogenesis, Nihon University School of Pharmacy

2007 Professor, Laboratory of Environmental Toxicology and arcinogenesis,                                                                        Nihon University School of Pharmacy

2014 Executive Professor, Laboratory of Environmental Toxicology and                                               Carcinogenesis, Nihon University School of Pharmacy

2018 Vice Dean, Professor, Laboratory of Environmental Toxicology and                                             Carcinogenesis, Nihon University School of Pharmacy

COMMITTEE ACTIVITIES

1997-2009 Board member, “Japanese Arsenic Scientist`s Society”

1998- Board member, “Japan Society for Biomedical Research on Trace Elements”

2000- Board member, “The Pharmaceutical Society of Japan”

2008- Member of the Ministry of the Environment Health Risk Comprehensive Technical Committee working group "Meeting on arsenic health risk assessment"

2008- Expert Committee Member of “Cabinet Office Food Safety Commission”

2010-2015 Vice Chair, “Japanese Arsenic Scientist`s Society”

2015- Chair, “Japanese Arsenic Scientist`s Society”

2018- Coordinator, “Japanese Society of Toxicology”, Metal Toxicity Section

EXTERNAL CMPETITIVE GRANTS AND OUTSOUCED RESEARCH FUNDS

1. Chinese Natural Science Foundation of International Cooperation and Exchanges (NSFC—JSPS)“Investigating of the Effect of Dimethylated Arsenic Species on Nrf2 in Arsenic-induced Human KeratinocytesTransformation”.

2. Grant-in-Aid for Scientific Research (No. 26460176) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

In addition, Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan gained more than 20 times.

3. Health Labour Sciences Research Grant for Research on Occupational Safety and Health (No. 23250301) from the ministry of Health Labour and Welfare of Japan.

4. Grant from the Food Safety Commission, Cabinet Office, Government of Japan (Research Program for Risk Assessment Study on Food Safety (No. 1102).

5. Grant from the Food Safety Commission, Cabinet Office, Government of Japan (Research Program for Risk Assessment Study on Food Safety, No. 1407).

6. In addition, Grant-in-Aid for High Technology Research and Academic Frontier Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

7. In addition, Outsourced Research Funds from Private Companies acquired more than 10 items.

RECENT REPRESENTATIVE PUBLICATIONS (Original Articles)

1. Differences in apoptotic signaling and toxicity between dimethylmonothioarsinic acid (DMMTA^V) and its active metabolite, dimethylarsinous acid (DMA^III), in HepaRG cells: Possibility of apoptosis cascade based on diversity of active metabolites of DMMTA^V. Yasuyo Shimoda, Koichi Kato, Satoru Asami, Masahiro Kurita, Hidetoshi Kurosawa, Masaharu Toriyama, Motofumi Miura, Akihisa Hata, Yoko Endo, Ginji Endo, Yan An, Kenzo Yamanaka. Journal of Trace Elements in Medicine and Biology. 2018, 50: 188-197.

2. Excretion Patterns of Arsenic and Its Metabolites in Human Saliva and Urine After Ingestion of Chinese Seaweed. Dapeng Wang, Yasuyo Shimoda, Hidetoshi Kurosawa, Jian Liu, Xiguo Xu, Xing Liu, Huanyu Jin, Jian Tong, Kenzo Yamanaka, Yan An. International Journal of Environmental Analytical Chemistry. 2015, 95(5):379-389.

3. Continuous Activation of Nrf2 and Its Target Antioxidant Enzymes Leads to Arsenite-Induced Malignant Transformation of Human Bronchial Epithelial Cells. Xu Yang; Dapeng Wang; Yuan Ma; Xiguo Xu; Yingying Zhao; Zhen Zhu; Xiaojuan Wang; Hanyi Deng; Chunchun Li; Fenfang Gao; Jian Tong; Kenzo Yamanaka; Yan An. Toxicology and Applied Pharmacology. 2015, 289:231-239.

4. Hypermethylation of Keap1 Gene Inactivates Its Function and Promotes Nrf2 Nuclear Accumulation Is Involved in Arsenite-Induced Human Keratinocyte Transformation. Dapeng Wang; Yuan Ma; Xu Yang; Xiguo Xu; Yingying Zhao; Zhen Zhu; Xiaojuan Wang; Hanyi Deng; Chunchun Li; Fenfang Gao; Jian Tong; Kenzo Yamanaka; Yan An. Free Radical Biology and Medicine. 2015,89:209-219.

5. A biological indicator of inorganic arsenic exposure using the sum of urinary inorganic arsenic and monomethylarsonic acid concentrations. Akihisa Hata, Hidetoshi Kurosawa, Yoko Endo, Kenzo Yamanaka, Noboru Fujitani, Ginji Endo. Journal of Occupational Health, 58, 196-200 (2016).

6. A novel metabolic activation associated with glutathione in dimethylmonothioarsinic acid (DMMTAV)-induced toxicity obtained from in vitro reaction of DMMTAV with glutathione. Hidetoshi Kurosawa, Yasuyo Shimoda, Motofumi Miura, Koichi Kato, Kenzo Yamanaka, Akihisa Hata, Yuko Yamano, Yoko Endo, Ginji Endo. Journal of Trace Elements in Medicine and Biology, 33, 87-94 (2016).

7. A biological indicator of inorganic arsenic exposure using the sum of urinary inorganic arsenic and monomethylarsonic acid concentrations. Akihisa Hata, Hidetoshi Kurosawa, Yoko Endo, Kenzo Yamanaka, Noboru Fujitani, Ginji Endo. Journal of Occupational Health, 58, 196-200 (2016).

8. Possible production of arsenic hemoglobin adducts via exposure to arsine. Takenori Yamauchi, Yuko Yamano, Kenzo Yamanaka, Akihisa Hata, Toshio Nakadate, Yoshiki Kuroda, Yoko Endo, Ginji Endo, Journal of Occupational Health 57(2), 161-168 (2014).

9. Arsine toxicity is induced by inhalation but not by percutaneous exposure in hairless mice. Koichi Kato, Kenzo Yamanaka, Yasuyo Shimoda, Yuko Yamano, Kasuke Nagano, Akihisa Hata, Yoko Endo, Mariko Tachikawa, Ginji Endo, Journal of Toxicological Sciences 39(2), 301-310 (2014).

10. Arsenic speciation analysis of urine samples from individuals living in an arsenic-contaminated area in Bangladesh. Akihisa Hata, Kenzo Yamanaka, Mohamed Ahsan Habib, Yoko Endo, Noboru Fujitani, Ginji Endo, Environ Health Prev Med 17, 235-245 (2012).

11. There are more than 100 SCI papers in total, more than 20 each in English and Japanese review articles and books.